No building shall hereafter be erected, nor shall any existing building be structurally altered, enlarged, rebuilt or moved, nor shall any open space contiguous to any building be encroached upon or reduced in any manner, except in conformity with the yard, lot width and area, building location, percentage of lot covered by building area, minimum habitable floor area, off-street parking space, off-street loading space and other applicable space and area regulations designed for the district in which such building or space is located, subject to such modifications thereof and such general provisions as are set forth in said district.