The zoning regulations and district as herein established have been made in accordance with a comprehensive plan and designed to lessen congestion in the streets; to secure safety from fire, panic and other dangers; to promote health and the general welfare; to provide adequate light and air; to prevent the overcrowding of land; to regulate signs; to avoid undue concentrations of population; to facilitate the adequate provision of transportation, water, sewerage, schools, parks and other public improvements. The regulations have also been made with reasonable consideration, among other things to the character of the district and its peculiar suitability for particular uses; and with a view to conserving the value to buildings and encouraging the most appropriate use of land throughout the city.