The location and size of the use, the nature and intensity of the operation involved in or conducted in connection therewith, its size, layout and its relation to streets giving access to it shall be such that traffic to and from the use and the assembly of persons in connection with it will not be hazardous or inconvenient to the neighborhood or conflict with the normal traffic of the neighborhood. In applying this standard, the Board shall consider, among other things, appropriate off-street parking, convenient routes of pedestrian traffic, particularly of children, and the relation to main traffic, to thoroughfares and to street and road intersections and the general character and intensity of development in the neighborhood.