The regulations and restrictions set forth herein and the boundaries of the various districts may from time to time be amended, supplemented, changed, modified or repealed. In case, however, of a protest against such changes, signed by the owners of 20% or more of either the area/lots included in such proposed change, or of those immediately adjacent thereto extending 250 feet there from, or of those directly opposite thereto extending 250 feet back from the street frontage of such opposite lots, such amendments shall not become effective except by the favorable vote of 4/5 of all the members of the Town Council.