To regulate and restrict both the location of trades and industries and the location of buildings designed for specific uses, and for said purposes to divide the City into districts. To prescribe for each such district the trades and industries that shall be permitted, those subjected to special regulation, and the uses for which buildings may not be erected or altered. Such regulations are designed to promote the public health, safety and general welfare and are made with reasonable consideration, among other things, to the character of the district, its peculiar suitability for particular uses, the conservation of property values and the direction of building development, in accordance with the City's Comprehensive Plan.