Manufacturing uses of a light nature and research and development or science-oriented industries that are free from any objectionable odors, fumes, dirt, vibration or noise detectable at the lot line. Such uses shall not be established without an application to the Zoning Administrator for a permit, which shall be accompanied by a certification by a registered engineer or architect indicating that fumes, odors, dirt, vibration or noise produced by the industry will not be detectable at the lot line. In the event of the denial of such permit, the applicant shall have the right of appeal to the Board of Appeals, in accordance with Article XVII of this chapter;