No building shall hereafter be erected nor shall any existing building be structurally altered, rebuilt or moved nor shall any open space contiguous to any building be encroached upon or reduced in any manner, except in conformity to the yard, lot width and area, building location, percentage of lot coverage by building area and by impervious surface, off-street parking space, off-street loading space and other space and area regulations designed in this chapter for the District in which such building or space is located, subject to such modification thereof and such provision as are set forth in this chapter.